Table of Contents
AFFILIATION
Oxytocin and Maternal Behavior Thomas R. Insel
Introduction
In its earliest studies, oxytocin has been proven to be transported via neurosecretory axons to the posterior pituitary, and released during parturition and nursing.
Research
Pedersen and Prange (1979)
What about lack of oxytocin?
Lesioning the PVN
Sheep vs Rats.
Why is Oxytocin effective?
Oxytocin Receptors.
Oxytocin Receptors.
Oxytocin content during Partuition.
How specific is oxytocin to maternal behavior?
How specific is oxytocin to maternal behavior?
How specific is oxytocin to maternal behavior?
Oxytocin and the neuroendocrine context
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GENE TARGETING APPROACHES TO NEUROENDOCHRINOLOGY: OXYTOCIN, MATERNAL BEHAVIOR, AND AFFILIATION YOUNG ET AL.
Young et al. examined the behavioral role of oxytocin in maternal and social behavior
Background
PART 1 : OT KNOCKOUT MICE
BEHAVIOR
BEHAVIOR
Resident-Intruder Paradigm:
Resident-Intruder Paradigm:
Is maternal behavior independent of oxytocin?
Once upon a time……..
Species Comparison
Part 2: Receptor Targeting
What may be the cause of differences in oxytocin-mediated behavior in different species?
PAPER #3
Purpose of experiment
Introduction
4 concepts studied in this article were:
Overall Method
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Measures of preference were:
EXPERIMENT 1: The Development of a Conditioned Place Preference to Pups in Postpartum and Virgin Female Rats (Concept #1)
Method: Factor #1
Factor #2: Effects of parity and of prior maternal experience were evaluated hence factor studied was the effect of maternal experience on caring for young (Fig 3)
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Factor #3:Examined the effects of deprivation duration in postpartum animals ONLY
RESULTS Effects of Variations in the duration of the conditioning regime on Conditioned Place Preference (CPP)
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Results for Factor #2 Effects of Prior Maternal Experience on Conditioned Place Preference
Results for Factor #3 Effects of Deprivation State on Conditioned Place Preference
DISCUSSION
EXPERIMENT #2: Conditioned Place Preference for Pup versus Food Reinforcement in Postpartum and Virgin Animals
Method
Results
Main Results and Conclusions
Main Results and Conclusions
Lunch time !!
EXPERIMENT 3: Effects of Maternal Hormones on the development of a CPP in response to Pup stimulation.
METHOD:
Results:
Discussion:
NEUROANATOMY REVIEW
EXPERIMENT #4: Effects of cis(Z)-Flupentixol on CPP in Postpartum Dams.
Method:
Results:
Discussion:
General Discussion:
Knowing that 1st. Time mothers are not as maternally responsive to their young, what advice would you give a teenage mother about giving up her baby for adoption?
COCAINE ALTERS THE ONSET AND MAINTENANCE OF MATERNAL BEHAVIOR IN LACTATING RATS
PURPOSE:
GENERAL METHOD
EXPERIMENT 1: PURPOSE: ESTABLISH A DOSE OF COCAINE THAT IS EFFECTIVE IN DISRUPTING FMB.
RESULTS:
EXPERIMENT 2
PROCEDURE:
RESULTS:
EXPERIMENT 3
PROCEDURE:
RESULTS:
DISCUSSION:
Why do dams on cocaine retrieve their pups but show no other maternal behaviour? What applications to humans could possibly be made?
Conclusion
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